Use Caution/Monitor. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Objective. Avoid or Use Alternate Drug. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Use Caution/Monitor. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Access your plan list on any device mobile or desktop. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Deferoxamine chelates iron. Consult your doctor before breast-feeding. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Venofer treatment may be repeated if necessary. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Do not double the dose to catch up. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Copyright(c) 2023 First Databank, Inc. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Fatal reactions have also occurred in situations where the test dose was tolerated. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Modify Therapy/Monitor Closely. FERAHEME Dosing & Administration - Feraheme Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Intravenous iron replacement can take place as total dose (as in the case of iron-dextran or iron carboxymaltose) or as split dose (in the case of iron sucrose). A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Avoid or Use Alternate Drug. Applies only to oral form of both agents. LBW = Lean body weight in kg. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. The elemental iron product used is Iron sucrose 20 mg/mL. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Avoid or Use Alternate Drug. All Rights Reserved. UpToDate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Administer Venofer only intravenously by slow injection or by infusion. This information is not individual medical advice and does not substitute for the advice of your health care professional. Applies only to oral form of both agents. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Total dose iron infusion: safety and efficacy in predialysis patients. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Use Caution/Monitor. Iron Sucrose Monograph for Professionals - Drugs.com VENOFER (IRON SUCROSE INJECTION,USP) 100mg ELEMENTAL IRON - DailyMed In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Venofer has not been studied in patients younger than 2 years old. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Treatment of anemia due to iron deficiency. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Each mL contains 20 mg of elemental iron. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . May increase risk of hypotension. Schweiz Med Wochenschr; 100(7):301-3. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Iron sucrose: 20 mg/mL. PDF Treatment Guideline - Gloucestershire Royal Hospital Applies only to oral form of both agents. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Minor (1)iron sucrose, benazepril. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Either increases effects of the other by pharmacodynamic synergism. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Applies only to oral form of both agents. Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. Venofer must only be administered intravenously either by slow injection or by infusion. Read our. Ren Fail. commonly, these are "non-preferred" brand drugs or specialty didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. *Repeat dose if iron deficiency anemia reoccurs. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. 1995 Mar-Apr;11(2):163-8. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. Iron deficiency anemia is the type of anemia caused by iron depletion. UpToDate. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Parenteral iron dose - UpToDate It can be expressed in mg per ml. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Intravenous iron sucrose for children with iron deficiency failing to Minor/Significance Unknown. DailyMed - VENOFER- IRON SUCROSE injection, solution Oral and parenteral products - see background option for oral products. If you log out, you will be required to enter your username and password the next time you visit. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). provider for the most current information. Minor (1)iron sucrose, captopril. J Lab Clin Med. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Applies only to oral form of both agents. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Either increases effects of the other by pharmacodynamic synergism. Human studies not conducted. Dosage form: injection, solution Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Applies only to oral form of both agents. Intravenous iron-dextran: therapeutic and experimental possibilities. The above information is provided for general Separate dosing of tetracyclines from these products. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. ONE DOSE. Minor/Significance Unknown. Applies only to oral form of both agents. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDD-CKD has not been established. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Pregnancy: Risk Summary-Clinical Considerations. Applies only to oral form of both agents. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Adding plans allows you to compare formulary status to other drugs in the same class. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Iron Deficiency Calculator Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. NOTES: Lab and/or medical tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be done while you are using this medication. Applies only to oral form of both agents. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. Venofer Injection Dosage Guide - Drugs.com Am J Hosp Pharm. Each mL contains 20 mg of elemental . Applies only to oral form of both agents. Treatment of iron deficiency anemia in adults - UpToDate Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Applies only to oral form of both agents. Applies only to oral form of both agents. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Use Caution/Monitor. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Use Caution/Monitor. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . All Rights Reserved. LBW = Lean body weight in kg. Max Dose. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. prescription products. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension.
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