Stevia does not cause side effects in most people. Stevia and diabetes: Safety, benefits, risks, and side effects Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Center for Food Safety and Applied Nutrition. In 1991, the FDA banned stevia over concerns that it was linked tocancer. Currently, there isnt enough evidence that whole-leaf stevia or crude stevia extract wont harm your pregnancy. View abstract. There are 11 steviol glycosides in the stevia leaf, responsible for giving stevia its sweet flavor. Effects of chronic administration of Stevia rebaudiana on fertility in rats. However, research supporting the safe use of less refined stevia compounds is still lacking. information is beneficial, we may combine your email and website usage information with A new study reveals the mechanisms behind, Millions of people routinely consume artificial sweeteners. Stevia can also interact with certain medications, so it is important to discuss stevia with a doctor before consuming or purchasing the product. Artificial sweeteners and cancer. One of the highly touted benefits of artificial sweeteners is that they have v irtually no calories. Stevia Side Effects - Is it safe? - The Living Well stomach discomfort or upset. View abstract. Factors that may increase the risk of stevia side effects include: There are many different types of steviol glycoside found in stevia, classified into five major groups. Some claim that it's entirely harmless, but new studies suggest that it may have some effects on your metabolism. Available at: https://www.cfsan.fda.gov/~rdb/opa-g252.html. They are non-nutritive. Res Commun Chem Pathol Pharmacol 1994;84:111-8. Can diet help improve depression symptoms? The Food and Drug Administration (FDA) considers stevia leaf extract safe for consumption, and it is unlikely to cause side effects in most people. Other side effects not listed may also occur in some patients. Hives. As a result, the FDA do not recognize stevia leaves and crude extracts as safe for consumption. A review on the improvement of stevia [Stevia rebaudiana (Bertoni). 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. 2018;122:132-142. Proc Natl Acad Sci USA 1985;82:2478-82. To avoid stevia stomach upset, be careful before purchasing stevia products. This article discusses the different forms of stevia and the side effects of this sugar alternative. If you have a bowel disease. Processed foods often contain a lot of sugar, yet it can be difficult to tell how much. Additional information about high-intensity sweeteners. Muscle Pain Aching muscles may also occur in some cases as a reaction to this sweetener. EFSA Panel on Food Additives and Flavourings (FAF), Younes M, Aquilina G, et al. Until research determines whether whole-leaf stevia is safe for everyone, get your doctors approval before using it regularly, especially if you have a serious medical condition such as diabetes, heart disease, or high blood pressure. The study also found that stevia may have antioxidant and anti-inflammatory properties. Select a condition to view a list of vitamins. Sweeteners made with Reb-A are considered novel sweeteners because theyre blended with different sweeteners, such as erythritol (a sugar alcohol) and dextrose (glucose). View abstract. The most notable of these ingredients is saccharin. Ashwell M. Stevia, Nature's Zero-Calorie Sustainable Sweetener: A New Player in the Fight Against Obesity. Click here for an email preview. However, studies suggest that consuming sugar substitutes such as stevia in place of sugar does not have an impact on overall daily calories intake or blood sugar levels. Prakash I, Dubois GE, Clos JF, et al. indigestion. Metabolism 2000;49:208-14. Though research on this issue is limited, it's possible that stevia may have an effect on the endocrine system, which includes glands that produce hormones. Profiles Drug Subst Excip Relat Methodol. In general, experts need to do more studies to learn what long-term health effects sugar substitutes might have on children. Stamataki NS, Scott C, Elliott R, McKie S, Bosscher D, McLaughlin JT. Stevia: Nature's Zero-Calorie, Sustainable Sweetener. heartburn. And it's best to use sugar substitutes for a short time, or just every once in a while. Researchers are checking to see if sugar substitutes affect cravings for sweets, the way people feel hunger and how the body manages blood sugar. Foods and drinks with aspartame can lead to serious health problems. Artificial sweeteners and other sugar substitutes - Mayo Clinic Since there's a variety of stevia products out there, ranging from pure stevia powder to liquid drops and extract, it's possible other sweeteners or products have been added to those mixes. J Nat Prod. Tomita T, Sato N, Arai T, et al. View abstract. If youre trying to lose weight, this aspect may be appealing. Hubler MO, Bracht A, Kelmer-Bracht AM. Stevioside. Learn about the pros and cons of sugar substitutes, also called artificial sweeteners. While that high level of consumption is not generally recommended, it demonstrates the vast volume of stevia you would need to consume for it to be considered unsafe. Consuming too much of any artificial sweetener may cause diarrhea, bloating, gas, or have a laxative. muscle cramps. Stevia During Pregnancy and Breastfeeding. View abstract. All rights reserved. Accessed Nov. 11, 2022. Stevia (Pure Via, Truvia) Artificial sweeteners are also called sugar substitutes, low-calorie sweeteners or nonnutritive sweeteners. However, the FDA has not approved stevia leaf and crude stevia extracts for use in food. Nettleton, J.E., et al. In general, artificial sweeteners are safe in limited amounts for healthy people, including pregnant people. (2012). Artificial sweeteners: Any effect on blood sugar? - Mayo Clinic Stevia products made with Reb-A are considered safe, even for people who are pregnant or who have diabetes. But because stevia is noncaloric, it's often used as a sugar substitute, especially for people hoping to manage diabetes or obesity. Low-dose stevia (Rebaudioside A) consumption perturbs gut microbiota and the mesolimbic dopamine reward system. Stevia Side Effects Mayo Clinic Recipes Lohner S, Toews I, Meerpohl JJ. Advertising revenue supports our not-for-profit mission. Stevia Side Effects Mayo Clinic - Explore Recent Since stevia is a plant-based extract, there's some possibility it can cause allergies or irritation in certain people. 1-15-2009;17(2):600-605. Stevia may also work as a better option than sugar for people wanting to maintain good oral health. Can Fam Physician. Accessed on: May 6, 2022. Stevia leaf extracts side effects. Here are 12 benefits of ginkgo biloba. It may also drop blood pressure too low or interact with medications that lower blood sugar. Allergic reactions. M S, M P, E T, et al. However, since stevia can have blood pressure and blood glucoselowering effects, as well as diuretic effects, those taking certain medications or who have certain health conditions should talk with their healthcare provider before consuming significant quantities of Stevia. In some people, stevia products made with sugar alcohols may cause digestive problems, such as bloating and diarrhea. View abstract. Consumption of stevia may be linked to cancer. Available at: https://www.accessdata.fda.gov/cms_ia/importalert_119.html. Stevia stomach upset, however, may be a cause for concern. J Ethnopharmacol 1999;67:157-61. Whole-leaf stevia and crude stevia extract, including stevia youve grown at home, are not safe to use if youre pregnant. Are the benefits of Stevia better than sugar? View abstract. DOI: Azad MB, et al. However, the FDA reversed the ban in 1995 after a follow-up study found no connection. People take stevia for obesity, high blood pressure, diabetes, and many. Some stevia side effects include potentially making it harder to lose weight. One of the Stevia side effects is Hypoglycemia, also known as low blood sugar, can be caused due to the increased consumption of Stevia. Poor digestion of sugar alcohol may cause abdominal pain, gas, bloating and diarrhea. Pope E, Koren G, Bozzo P. Sugar substitutes during pregnancy. High doses or heavy, long-term use of stevia may worsen common pregnancy symptoms by increasing the workload on organs such as the kidneys, bladder, and heart. WebMD does not provide medical advice, diagnosis or treatment. (2019). Rebecca Valdez is a registered dietitian nutritionist and nutrition communications consultant, passionate about food justice, equity, and sustainability. Exp Biol Med (Maywood.) View abstract. That's because sugar substitutes often are low in calories or have no calories. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. While most people will not experience any side effects from consuming it, stevia blends containing sugar alcohols may cause gastrointestinal symptoms in people with sugar alcohol sensitivity. Steviol glycosides are natural constituents of the leaves of Stevia rebaudiana (Bertoni) Bertoni, a plant native to parts of South America and commonly known as Stevia. They offer the sweetness of sugar without the calories. Health effects of the use of non-sugar sweeteners. Many people choose to replace sugar with stevia to reduce their calorie consumption. If you use stevia now and then, it may not be enough to impact your blood sugar. Safety of a proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: to expand the list of steviol glycosides to all those identified in the leaves of Stevia Rebaudiana Bertoni. Some have no calories. Effects of the Daily Consumption of Stevia on Glucose Homeostasis, Body Weight, and Energy Intake: A Randomised Open-Label 12-Week Trial in Healthy Adults. Garner C. Nutrition in pregnancy: Assessment and counseling. Ginkgo biloba has been widely cultivated across the globe for a variety of uses, most of which are medicinal. Taware, A. S., Mukadam, D. S., and Chavan, A. M. Antimicrobial Activity of Different Extracts of Callus and Tissue Cultured Plantlets of Stevia Rebaudiana (Bertoni). What Are the Negative Effects of Stevia? - MedicineNet Clin Ther 2003;25:2797-808. Cardiovascular health: Insomnia linked to greater risk of heart attack. Certain chemicals in stevia are commonly used as natural food sweeteners. This article explains what whole eating is and shares 11 simple ways clean up your. But artificial sweeteners can help some people enjoy sweetness without excess calories. (2013). Food Chem Toxicol 2008;46 Suppl 7:S40-6. D'Agostino, M., De Simone, F., Pizza, C., and Aquino, R. [Sterols in Stevia rebaudiana Bertoni]. It varies by a person's weight and the type of sugar substitute used. View abstract. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. J Agric Food Chem 2008;56:3777-84. J Agric.Food Chem 2-8-2006;54(3):785-789. Dizziness Some people have reported feeling dizzy after taking stevia. They add calories to your diet. Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle. People thought that artificial sweeteners wouldn't have the same effect. stevia leaf extract (greater than 95% steviol glycosides) was determined to be generally recognized as safe in 2008 by the FDA. Almost everyone likes a sugary snack. Metabolism 2004;53(10):1378-1381. It is therefore important to buy products certified to contain at least 95 percent steviol glycoside, and that contain no artificial or synthetic sweeteners. A study published in June 2019 in Proceedings of the National Academy of Sciences of the United States of America delved into how and why this plant naturally creates such a high level of sweetness. They are going to affect everyone differently. Artificial sweeteners: Weight loss friend or foe? The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Melis MS. Liver side effects: Research on the impact of stevia on the liver is preliminary and . Although stevia may help control blood sugar in people with diabetes, it was also once thought that long-term or heavy stevia consumption might cause hypoglycemia or low blood sugar. The agency doesn't consider sugar alcohols to be food additives. 2020;150(5):1126-1134. (2015). Artificial sweeteners are many times sweeter than sugar. Melissa Nieves, LND, RD, is a registered dietitian working for a private practice. Description and Brand Names - Mayo Clinic - Mayo Clinic Clopidogrel (Oral Route) Side Effects - Mayo Clinic Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Which is a leading reason it's studied for use in diabetic patients. Brusick DJ. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. However, erythritol is better tolerated than most sugar alcohols, according to the Calorie Control Council, because it is absorbed and eliminated quickly from the body. However, one noted limitation in this study is that it took place in a laboratory setting, rather than in a real-life situation in a persons natural environment. If you're living with a rare genetic disease called phenylketonuria. Stamataki NS, Crooks B, Ahmed A, McLaughlin JT. Sugars, granulated. View abstract. View abstract. In addition to some of stevia's touted benefits as a sugar substitute in helping people lose weight or improve diabetes management, it has been linked to a number of other potential health benefits, though these are still being explored further. Pezzuto JM, Compadre CM, Swanson SM, et al. Stevia - Wikipedia Agency Response Letter: GRAS Notice No. There's concern that raw stevia herb may harm your kidneys, reproductive system, and cardiovascular system. Sugar substitutes also don't raise the level of sugar in the blood. By Rebecca Valdez, MS, RDN A study published in December 2015 in Physiology & Behavior notes that certain non-nutritive sweeteners have been linked to a reduction in dental cavities. When used as a sweetener or to flavor foods, experts do not consider highly purified stevia to cause adverse side effects. These ingredients may get your tastebuds used to sweetness. American Diabetes Association. It may take some trial and error to get the texture and level of sweetness you like. Truvia vs. Stevia: Whats the Difference? The FDA says stevia glycosides, such as Reb-A, are generally recognized as safe. They havent approved whole-leaf stevia or crude stevia extract for use in processed foods and beverages due to a lack of safety information. information and will only use or disclose that information as set forth in our notice of Stevia contains chemicals that are 200-300 times sweeter than sucrose sugar. Metabolic effects of non-nutritive sweeteners. Stevia sweeteners don't have calories and are a good choice for people trying to lose weight. https://www.uptodate.com/contents/search. People with allergies to ragweed, chrysanthemums, marigolds or daisies should be careful when trying stevia, according to Tufts Medical Center Community Care. 2017;41(3):450-457. Since then, research has shown that those findings don't apply to people. J Nutr. We dig into the ingredients of popular zero-regret ice creams and find out if our bodies can take the hype. Stevia can cause gastrointestinal side effects in some people, including gas, nausea, and bloating. blood pressure conditions and medications. And while the study published in December 2015 in Physiology & Behavior also investigated whether stevia can impair gut flora in the digestive tract, more research is needed to solidify the link. Sugar alcohols, stevia and luo han guo can cause bloating, gas and diarrhea. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Anything that actively lowers blood pressure can cause health complications with excessive, long-term use. Rebaudioside affords hepatoprotection ameliorating sugar sweetened beverage- induced nonalcoholic steatohepatitis. U.S. Food and Drug Administration. View abstract. Import Alert 45-06: Detention without Physical Examination of Stevia Leaves, Crude Extracts of Stevia Leaves and foods Containing Stevia Leaves and/or Stevia Extracts. A 2020 study found that people with type 2 diabetes who drank 1 cup of stevia-sweetened tea per day for 8 weeks had no significant changes in their blood glucose levels. Honey is a sweet fluid made by honeybees using the nectar of flowering plants. Stevia is safe for most people to use. View abstract. It may also damage. Stevioside may also help decrease some mitochondrial pathways that help cancer grow. Is Stevia Safe For 2020? Mutagenic Side Effects Examined This has since been proven highly unlikely, except in individuals with abnormally low blood sugar levels. Chan P, Tomlinson B, Chen YJ, et al. View abstract. This is a common mystery with herbal products. Nutrients. How stevia may help to control blood sugar. Some people are at an increased risk of developing side effects from regular stevia use. Stevia is a sugar substitute made from the leaves of the stevia plant. https://www.fda.gov/ora/fiars/ora_import_ia4506.html (Accessed 21 April 2004). Can whole-grain foods lower blood pressure? It's possible that different types of products may cause stevia stomach upset more than others. Planta Med 2001;67(9):796-799. Jeppesen, P. B., Gregersen, S., Rolfsen, S. E., Jepsen, M., Colombo, M., Agger, A., Xiao, J., Kruhoffer, M., Orntoft, T., and Hermansen, K. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Accessed Nov. 15, 2022. Wasuntarawat C, Temcharoen P, Toskulkao C, et al. If you are concerned about the potential side effects of stevia, research shows that it is safe to consume and unlikely to cause side effects in most people. View abstract. Sugar alcohols, stevia and luo han guo can cause bloating, gas and diarrhea. Stevia is not known to cause inflammation. For example, Truvia is a blend of Reb-A and erythritol, and Stevia in The Raw is a blend of Reb-A and dextrose (packets) or maltodextrin (Bakers Bag). Its unclear if occasional stevia use in lower amounts would have the same impact. Honey - Mayo Clinic Klongpanichpak, S., Temcharoen, P., Toskulkao, C., Apibal, S., and Glinsukon, T. Lack of mutagenicity of stevioside and steviol in Salmonella typhimurium TA 98 and TA 100. And there are other possible problems. Can ice cream really be healthy? Available at: https://www.cfsan.fda.gov/~rdb/opa-gn08.html. Some people have allergic reactions to steviol glycosides that . Regul Toxicol Pharmacol 2008;51:37-41. Some stevia products contain added sugar alcohols that may cause unpleasant symptoms in individuals that are very sensitive to the chemicals. Potential complications with the overuse of stevia products during pregnancy include: Researchers still do not understand the full range of risks associated with stevia. For these reasons, it may be useful for people taking steps to control . Two minor diterpene glycosides from the leaves of Stevia rebaudiana. The hidden hazardous effects of Stevia and sucralose consumption in male and female albino mice in comparison to sucrose. Reb-A is about 200 times sweeter than table sugar. Some positive and others negative. If you are a Mayo Clinic patient, this could This article looks at its benefits, potential risks, sources, and the research behind its health, New research shows that an enzyme produced by the liver causes inflammation in the abdominal fat, raising the risk of insulin resistance and diabetes, The natural, no-calorie sweetener stevia may help people with diabetes to control their blood sugar levels. Some sugar substitutes also are sold on their own in packets or other containers. FoodData Central. Common side effects of stevia include: Allergic reaction This document does not contain all possible side effects and others may occur. You can learn more about how we ensure our content is accurate and current by reading our. Despite this, stevia contains no calories or carbohydrates, compared to sugar which has 15 calories and 4 grams of carbohydrates per teaspoon. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. When you eat a sugary treat, your body produces the hormone insulin to help stabilize the sugar in your blood. Many argue that this means theres nothing natural about them. What is Stevia Made from? | Gainful (2018). https://www.fda.gov/consumers/consumer-updates/how-sweet-it-all-about-sugar-substitutes. All rights reserved. The following are few of the asserted side effects or dangers of stevia: 1. 2002;25(11):1488-1490. Frequently Asked Questions Effect of Stevia rebaudiana on glucose tolerance in normal adult humans. Stevia's taste has a slower onset and longer duration than that of sugar, and at high concentrations some of its extracts may have an aftertaste described as licorice -like or bitter. Baker-Smith C, et al. The study concluded that stevia may act as an endocrine disruptor, or a chemical that can interfere with hormones. Stevia is a nonnutritive sweetener. Neurosci.Lett 4-17-2009;454(1):72-75. According to a 2015 review, there are very few reported cases of stevia allergy. ", Contemporary Clinical Trials Communications: "Preliminary Analysis of the Effect of Stevia (Stevia rebaudiana) in Patients With Chronic Kidney Disease (Stage I to Stage III)", Physiology & Behavior: "Metabolic Effects of Non-Nutritive Sweeteners", Canadian Medical Association Journal: "Nonnutritive Sweeteners and Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies", Memorial Sloan Kettering Cancer Center: "Stevia", Food and Chemical Toxicology: "Steviol Glycoside Safety: Are Highly Purified Steviol Glycoside Sweeteners Food Allergens? DOI: Sharma N, et al. However, more research needs to be done to provide conclusive evidence on weight management, diabetes and other health issues. All rights reserved. View abstract. Studies using rat embryos have established that stevia did not affect pregnancy or fertility outcomes and was non-toxic to fetal tissues. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Routine consumption of these sweeteners may also lead to a higher risk of cardiometabolic disease. For purposes of this article, stevia refers to Reb-A products. 4. Stevia might have an effect like a water pill or "diuretic." (2013). Nutrients. Monk fruit and stevia are the latest buzz-worthy candidates for your morning cup of coffee or tea. Stevioside induced ROS-mediated apoptosis through mitochondrial pathway in human breast cancer cell line MCF-7 [Abstract]. According to a 2020 review, "In addition to its hypoglycemic property, the stevia plant also exhibits antibacterial, anti-inflammatory, hypotensive, antiseptic, diuretic, anti-fertility and cardiotonic properties." Below are some of the main advantages associated with stevia use: 1. High doses or heavy, long-term use of stevia may worsen common pregnancy symptoms by increasing the workload on organs such as the kidneys, bladder, and heart. Stevia made with Reb-A is safe to use in moderation during pregnancy. 1. A snack labeled low sugar or no sugar may not be the most nutritious choice. https://www.cancer.gov/about-cancer/causes-prevention/risk/diet/artificial-sweeteners-fact-sheet. View abstract. Artificial sweeteners can be a short-term way to help some people lessen their use of sugar and lose or manage weight. However, some of the common counterfeit ingredients found in stevia mixtures and formulas are linked to serious complications and may cause birth abnormalities. Accessed Nov. 11, 2022. Swithers SE. When you want to add a pinch of sweet taste to your food or drinks without the pitfalls of sugar, you may find yourself turning to sugar alternatives like stevia. Government health agencies oversee ingredients that product-makers add to food. Effects of stevia on glycemic and lipid profile of type 2 diabetic patients: A randomized controlled trial. Uncontrolled Blood Sugar: How Dangerous Is It. Thank you, {{form.email}}, for signing up. U.S. Food and Drug Administration, December 2008. The study found stevia lowered total cholesterol, LDL (bad) cholesterol, and triglycerides with no negative side effects. AlDeeb OA, Mahgoub H, Foda NH. Whole foods, such as fruits and vegetables, usually have the best mix of nutrients for the body. 2016;2016:5967907. As a type of steroid, steviol glycosides can interfere with hormones controlled by the endocrine system. It found that many stevia glycoside derivatives were toxic to specific leukemia, lung, stomach, and breast cancer cell lines. Office of Regulatory Affairs. The Side Effects of Truvia | Healthfully Yasukawa, K., Kitanaka, S., and Seo, S. Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. You may opt-out of email communications at any time by clicking on Daily stevia consumption may stop or slow down metabolism and so, interrupt with the conversion process of food into energy. This is because stevia can lower blood sugars and blood pressure, and act as a diuretic. Taking stevia along with medications that lower blood pressure might cause blood pressure to go too low. U.S. Food and Drug Administration, December 17, 2008. CFSAN/Office of Food Additive Safety. However, whole stevia leaf is not approved by the FDA and is not generally recognized as safe for consumption by anyone, especially pregnant people. U.S. Food and Drug Administration. [7] Sugar substitutes also are not linked to a higher risk of cancer in people. Principles and methods for the risk assessment of chemicals. Theyre made from a highly refined stevia leaf extract called rebaudioside A (Reb-A). https://www.dietaryguidelines.gov. People who may be more likely to experience side effects from stevia include people taking medications to lower blood pressure or blood glucose or those diagnosed with: Stevia leaf extract is safe to consume when pregnant or breastfeeding. DOI: Pepino MY. Although hypersensitivity to sugar alcohol is rare, its symptoms can include: Several studies using rodent and human cell cultures have demonstrated the potential gastrointestinal benefits of steviol glycosides. Accessed Nov. 11, 2022. Chan P, Xu DY, Liu JC, et al. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Is there a link between stevia and cancer? 4 Stevia Side Effects: Weighing Stevia's Pros and Cons Ac., CYT, 12 Benefits of Ginkgo Biloba (Plus Side Effects & Dosage). World Health Organization. Stevia is a non-nutritive or zero-calorie sweetener made of steviol glycosides. The same study also suggested nonnutritive sweeteners may induce glucose intolerance and metabolic disorders. Your lithium dose might need to be changed. Low-calorie sweeteners increase fat formation, study finds, The benefits and risks of acesulfame potassium. Did you know artificial sweeteners may actually increase the risk of diabetes or worsen your condition? Stevia might lower blood pressure. Both the FDA and European Commission concluded that the number of individuals who are hypersensitive to stevia or at a risk of having an allergic response to it is low. Geuns JM. Learn more about stevia side effects to educate yourself on how to incorporate sweeteners into your diet.
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